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[] MOF-mediated hyperacetylation of ATP5B disrupts oxidative phosphorylation, leading to cardiomyocyte energy deficiency, which drives mitochondrial crista loss, fibrosis, and ventricular enlargement, ultimately culminating in HF

Gandhi PU, Gaggin HK, Sheftel AD et al (2014) Prognostic usefulness of insulin-like growth factor-binding protein 7 in heart failure with reduced ejection fraction: a novel biomarker of myocardial diastolic function

doi: 10.1016/j.tips.2018.10.005

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In addition to this research discussed in the FY 2021 rulemaking, we have also considered more recent research comparing Medicare FFS rates, MAO rates, and rates of other commercial payers, some of which used data that was made public under the provisions of the Hospital Price Transparency regulations