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The three intracellular loops would be more involved in G protein interaction (Metzger and Ferguson, 1995

Drmic et al., Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME, World J

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Similar effects were observed in mice and rats on administration of a single dose of 125 mg iron/kg

Given its essential role in the detoxification of lipid hydroxy peroxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to induce ferroptosis as a mean of eradicating myeloid leukemia cells

However, it does not trigger lipid peroxidation-mediated ferroptosis [139] (Figure 5E)