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Aged Human Skin Accumulates Mast Cells with Altered Functionality That Localize to Macrophages and Vasoactive Intestinal Peptide-Positive Nerve Fibres

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[] In state of obesity, the neuronal signals triggered by hepatic extracellular signal-regulated kinase (ERK) activation transmit to the brain through the afferent fibers of splanchnic nerves, after modulation of the signals in the brain, the efferent fibers of the vagal nerves release multiple neural factors, such as acetylcholine (ACh), pituitary adenylate cyclase activating polypeptide, and vasoactive intestinal polypeptide, and then, these neurotransmitters synergistically promote -cell proliferation through a FoxM1-dependent mechanism

Chen SY, Wu CF, Wu C, Chan CC, Hwang JS, Su TC (2022) Urban fine particulate matter and elements associated with subclinical atherosclerosis in adolescents and young adults

Barrier Strengthening: It enhances the production of ceramides and free fatty acids, improving the skins barrier function and retaining moisture