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Reduced MTHFR activity can lead to elevated homocysteine levels and impaired folate-dependent processes like DNA methylation and neurotransmitter synthesis

Vitamin B12 also may be involved in maintaining sulfhydryl (SH) groups in the reduced form required by many SH-activated enzyme systems

Results: Significant copy number loss in UBE2D3 gene locus was observed in human HCC, resulting in significant downregulation of UBE2D3 mRNA levels compared to non-tumor liver tissue

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

The targeted metabolomics data, including raw mass spectrometry files, have been deposited in the MetaboLights-compatible Metabolonote repository under accession number MPST000150

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