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Nat Commun (2022) 13(1):6823

Cancer 42 , 3340 (2002)

One of the most important of those signals is GHK-Cu a small copper-binding peptide that plays a central role in collagen synthesis, wound healing, and gene-level tissue repair

Furthermore, topical application of retinoids on melasma lesions could potentially be associated with secondary hyperpigmentation as a result of drug-induced irritation (Pitowska et al., 2022)

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Some researchers start here for the first 12 weeks to assess tolerance before moving up