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Investigations into the role of the RA[A]S in the brain, and more specifically in dopaminergic neurons, have deepened our understanding of neurodegeneration in PD

Here, certain amino-acid side-chains in the active site (specifically, their respective chemical properties), combined with the enzymes shape, lead to only one or at most a few types of molecules that can bind long enough for an irreversible chemical reaction to take place

European Journal of Gastroenterology & Hepatology

doi: 10.21037/atm-21-6081 25 van TienhovenXAde Chvez GascnJRCano-HerreraGNehmeJASSouroujonTGonzalezMFBet al

These pathways are interrelated, and dysregulation of one will affect the other

L.Ortega-VillasanteC.et al