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These inflammatory processes can exacerbate synaptic dysfunction and neuronal loss, which are hallmarks of AD pathology

This is a network of nerves transmitting signals from the spine to the shoulder

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Gao et al., 2012)

Mechanistically, DUSP15 overexpression increases mitochondrial HSP70 protein levels and then restores the downregulation of mitochondrial unfolded protein response in the heart tissue of diabetic cardiomyopathy mice [202]