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Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib

Cellular signaling cascades ultimately affect gene expression regulation

76 Human hepatocyte models are a next logical step, and thus more investigations need to be carried out before either serotonin or SFN can be realistically considered on the therapeutic level

93 LEP enhances IL-1-induced production of MMP-1, MMP-3, and MMP-13 in human OA cartilage, 94 indicating its role as a catabolic regulator of cartilage metabolism

No intervention was performed for ethical reasons, and differences in dosage (500 mg vs 1g), brands (Doliprane, Dafalgan, Paracetamol Mylan), and co-administration with other pharmaceuticals were observed between intakes and pregnant women

In preclinical mouse models, we and others showed that increased hepatic ammonia due to the loss of GLUL or increased ammonia import via SLC4A11 can promote HCC development ( 7 , 8 )