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Parisi et al., 2008a

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In support of this model, we observed that the effect of PHGDH inhibition on the ATF-4 response was specific to serine and glycine deprivation, since treatment with PH755 did not prevent the induction of ATF-4 targets in response to ER stress (Supplementary Figure 5d)

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17,18 However, excessive Nrf2 activation can disrupt cellular balance, highlighting the need for regulated activity