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Sourcing amino acidsa key regulator of T cell protein synthesis T cells can obtain the amino acids needed to fuel protein synthesis by four main mechanisms: uptake from the environment via amino acid transporters [50, 51], degradation of extracellular proteins internalized by macropinocytosis [52], metabolic pathways that convert other metabolites into amino acids [36, 53], and degradation of intracellular proteins via autophagy [54]

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Zhang Q, Hu Y, Hu JE, Ding Y, Shen Y, Xu H