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Nicotine is the substance that makes tobacco addictive

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Tobacco Facts: How You Become Addicted to Cigarettes Tobacco facts show inhalation of nicotine via cigarette smoking produces the most rapid delivery of nicotine to the brain, with drug levels peaking within a few seconds of inhalation

Like other nicotine-containing products, HTPs lead to a nicotine-related acute increase in arterial stiffness and cardiovascular stress, just like combustible cigarettes, which links these products with an increased cardiovascular risk

Secondhand or passive smoke also causes dangerous adverse health effects in human beings (Vainio, 1987)