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Metformin reduced mortality in diabetic patients infected with tuberculosis during tuberculosis treatment, and the improved mortality rate was similar to that of non-diabetic tuberculosis patients (131)

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To downregulate TfRs and limit the amount of surface binding or endocytosis in HL-60 cells, 100 M human holo-Tf (Sigma-Aldrich) in endotoxin-free PBS (EMD Millipore) was added to the medium for overnight incubation