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This dotted appearance is observed in other studies as an indicator of fragmented mitochondria in unhealthy and oxidatively stressed cells (Jeek and Plecit-Hlavat, 2009)

Reducing Circulating Triglyceride Levels It is clear, therefore, that there are a variety of ways in which the triglyceride-containing particles in hypertriglyceridemic plasma could contribute either directly or indirectly to multiple aspects of atherosclerotic lesion development

doi: 10.1161/01.res.0000258450.44413.96, 3

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This, in turn, upregulates SLC7A11 expression, enhances the levels of GPX4, GSH, and SOD, and reduces Fe 2+ and MDA levels, thereby suppressing ferroptosis and promoting BV2 cell survival

7 Future perspectives Model organisms are important substitutes for human studies to facilitate and expedite translation of preclinical studies