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High-fat diet protects the blood-brain barrier in an Alzheimers disease mouse model

In this study, a dual stimuli-responsive prodrug nanosystem (MSNs-ss-SA) was synthesized by conjugating SA to functionalized disulfide-doped mesoporous silica nanoparticles (MSNs-ss-NH 2 ) via amide bonds to facilitate the efficient delivery of SA and bioavailable silicon concurrently