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Most patients feel benefits within one hour of administering a single spray of pure GSH into each nostril

10.1007/s00787-017-1022-y 3 Ardebili DorriS.HosseinzadehH.AbnousK.Vahdati HasaniF.Yazdian RobatiR.RazaviB

This explains why mitochondrial dysfunction directly affects the stability of the nuclear genome and cytoplasmic metabolism (Kispal, Prohl and Lill 1999