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Nicotine is a cholinergic agonist and is the principal psychoactive compound in tobacco linked to cigarette addiction

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While the remaining eleven biomarkers did not significantly differ between the two types of users, most (8/11) appeared to have higher levels in discount brand smokers, such as xylene (2-MHA), acrylonitrile, 1,3-butadiene, propylene oxide, acrolein, crotonaldehyde, lead, and 1-hydroxypyrene

Released in March 1991, it peaked at No