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It is suggested that phosphorylation impacts on the allosteric regulation of MTHFR via altering the equilibrium of active and inactive states of the enzyme, favoring the inactive state which SAM preferentially binds 21

doi: 10.1016/S0166-2236(96)10069-2

J Gastroenterol Hepatol 29(4):678687 Ezhilarasan D (2023) Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms

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This effect may be mediated, at least in part, by an increase in neurotrophic factors and acetylcholinesterase-inhibiting activity, as well as a reduction in amyloid burden and tau pathology in the cerebral cortex

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