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Oral Melanotic Macule: Symptoms and Treatment Skinsight Dark Spot on Lip: Harmless or Serious? What to Check First Venous Lake Lip vs Melanoma: Differences Atrium Dental Pigmented macular lip lesion Clinical Advisor Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications ScienceDirect

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