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Other pathways, such as AMP-activated protein kinase (AMPK), phosphoinositide 3-kinase/protein kinase B (AKT), cAMP/protein kinase A (PKA)/cAMP response element-binding protein (CREB), and signal transducer and activator of transcription 3 (STAT3)/Snail, are involved in other crucial FNDC5/irisin functions (Wang et al., 2022

There is also the possibility that behavioural improvements in children with ASD are seen because an improvement in gut health provides relief from the discomfort of gastro-intestinal issues, also common in ASD

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