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Stridh H, Kimland M, Jones DP, Orrenius S, Hampton BM (1998) Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis

Steroids, especially when taken in high doses (supraphysiologic) or for a long time, can lead to a variety of side effects, some of which can be serious and long-lasting

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Consequently, NRF2 activity increases, leading to the elevated expression of antioxidant enzymes such as glutathione S-transferase, NAD(P)H quinone oxidoreductase 1, and heme oxygenase-1 (260)

This suggests that no other SAM sites exist in the filament beyond S2, but it is also possible that mutation of these residues could alter another putative cryptic SAM binding site indirectly

The gut microbiome and its impact on the brain