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Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects

By modulating many pathways (such as p53, FOXO, Nrf2, NF-B), among other things, it can participate in the control of oxidative stress, inflammatory reactions, apoptosis, and the breakdown of energy

Overall, although these strategies highlight the impressive preclinical potential of NM-based macrophage immunotherapy, very few have directly entered the clinical arena

Booth CH, Mutkus L, Bussard K, Spaeth E, Andreeeff M, Marini FC

Thus, combination with BSO, cisplatin and TMZ turned out to be an extremely powerful approach to improve cytotoxicity in glioma, thus providing an exciting alternative for glioma treatment

J Alzheimer Dis 2008, 15: 211-222