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As will be further discussed in section Aging and age retaled diseases, IGF-I and GH levels also decrease with aging (somatopause)[169], reason why a potential strategy for reversing these senile changes in thymic vitality may involve administration of either GH or IGF-I, which have been examined for their potential to expand T-cell populations in animals[170]

Gastroenterology 96, 1989

The optimal oral bioavailability for a drug candidate is influenced by a set of interrelated physicochemical parameters that define its favorable chemical space

Given that the underlying conditions MOTS-c targets insulin resistance, metabolic aging develop over years, it's reasonable to expect meaningful assessment would require at least 8-12 weeks of use alongside objective metabolic monitoring, such as HbA1c, fasting insulin, and continuous glucose data

J Comp Neurol 370: 536-550

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