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Am J Physiol 258 :G185G190

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Vandewalle J, Luypaert A, De Bosscher K, Libert C (2018) Therapeutic mechanisms of glucocorticoids

These benefits come from chocolates ability to promote production of the vasodilator Nitric Oxide as well as the anandamide within, a cannabinoid compound (like CBD) that binds to receptors in the brain to alter mood and brain activity

Its anti-inflammatory properties stem from its ability to inhibit pro-inflammatory mediators such as NF-B, IL-6, and TNF- (84)

When combined with agents such as rapamycin and GBM-specific neoantigens, vaccinia virus or Myxoma virus expressing the IL-15R-IL-15 fusion enhances survival