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Any kind of inhaled irritant, including nicotine and any of the chemicals that are in the e-cigarette, will cause irritation of the airways, interfere with immune-boosting white cell production, and lead to cough and bronchitis, says Dr

Barry Manilow

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It represents the most sensitive measure of airflow in peripheral airways and is indicative of airflow obstruction, which is reduced in the early stages of SAD (75) and it is considered more accurate in detecting small airway disease than the forced expiratory volume in 1 s (FEV1) (76)

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