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All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals and were approved by the Duke University Institutional Animal Care and Use Committee (IACUC)

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In the November 2011 final rule (76 FR 67808), in alignment with the statutory requirement at section 1899(b)(2)(D) of the Act, CMS established that, at a minimum, an ACO shall have at least 5,000 such beneficiaries assigned to it to be eligible to participate in the Shared Savings Program under 425.110

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Carotenoids are provitamins (i.e., precursors of vitamin A) produced by plants that can be converted into retinal by the human body