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Targeted delivery minimizes systemic exposure and focuses action on the tissue that requires repair, reducing off-target proliferation risk

When taking into consideration that our review has exclusively focused upon studies of apparently healthy individuals and not those who have already developed disease, all statistically significant results in exposed groups may be considered as early modifications related to disease onset

This advanced architecture is engineered to render a synchronized response to the tumor microenvironment, thereby optimizing the spatiotemporal release of both drugs to maximize antitumor effects and overcome resistance [224]

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Likewise, inducing pyroptosis alone fails to elicit effective tumor suppression, underscoring the importance of combining pyroptosis inducers with ICIs for the treatment of cold tumors [348, 349]

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