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PMID: 64 LiY.DengS.YangP.WuJ.ZhaoT.ChenD.et al

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(This explains why hydroquinone has long been used for melasma removal , where brown or gray-brown patches of skin appear on foreheads, cheeks, chins and bridge of the nose.) In smaller doses (of at most 2%), hydroquinone can be purchased over-the-counter but pigment removal products with at least 4% hydroquinone concentration (considered to be the most effective concentration), require a prescription from a skin care specialist

83 The folate cycle uses glycine and tetrahydrofolate (converted from folic acid) and produces intermediates (5,10-methylene-tetrahydrofolate and 5-methylene-tetrahydrofolate) to supply methyl groups for purine synthesis