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In vitro functional analyses confirmed their mature hepatocyte characteristics: they showed high transcription and protein expression of ALB, A1AT, CYP3A4, and CYP2C9, comparable to primary human hepatocytes (PHs)

Hepatocyte growth factor/scatter factor-induced intracellular signalling

For all three methods of delivery there was a clear dose-response relationship between performance on the water maze test and administration of Dihexa

Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)

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10.1002/(SICI)1097-4547(20000215)59:4 3.0.CO;2-9 Summary Keywords zebrafish, hair cell protection, hearing loss, aminoglycosides, hepatocyte growth factor, lateral line Citation Uribe PM, Kawas LH, Harding JW and Coffin AB (2015) Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure