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Nicotine itself is also not biologically neutral

To help prevent substance use at all ages, we must make sure that children have the skills to resist peer pressure, reduce stress, and increase communication

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Nicotine may likewise reduce saliva production and slightly increase fluid loss, contributing to dryness in the mouth, throat, and airways

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At a valuation of $38 billion, the deal would be the second-biggest such investment this year and among the 10 largest of all time, according to data compiled by Bloomberg