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Arnicolide D not only increases the production of reactive oxygen species (ROS) and decreases mitochondrial membrane potential in BC cells, but it also significantly promotes the expression of PARP-1, enhances the nuclear translocation of apoptosis-inducing factor (AIF), and reduces the level of AIF in mitochondria, thereby inducing the occurrence of apoptosis in a ROS-dependent manner [154]

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Through inhibition of excessive lipopolysaccharide and inflammatory mediator production, curcumin fortifies intestinal barrier integrity, attenuates uremic toxin translocation, and mitigates renal fibrogenesis and NLRP3 inflammasome activation (Xu X

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Within the broad scope of research topics in the literature, the papers selected for this review focused on e-cigarettes in the context of key topics related to tobacco harm reduction, including aerosol chemistry studies, toxicological assessments of e-cigarette aerosols with in vitro and in vivo in comparison to cigarette smoke, and clinical investigations that examined the short- and long-term benefits of switching to e-cigarettes for adult smokers (Table 1)