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10.3389/fphar.2021.774414 72 ShirwaikarA.ShirwaikarA.RajendranK.PunithaI

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iScience 26 , 106150 (2023)

However, it should be noted that supplementation of betaine in individuals with CBS deficiency, without sufficient dietary methionine restriction, leads to methionine excess with severe clinical consequences (Schwahn et al, 2019)