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The purpose of this mode of therapy is to provide the patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimizing certain undesirable effects, including pituitary-adrenal suppression, the cushingoid state, corticoid withdrawal symptoms, and growth suppression in children

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However, such a rough calculation does not adjust for evolving population demographics, including trends that may result in hardening, the term for what would happen if tobacco use concentrates increasingly among those who have the most difficulty quitting, a particular concern among marginalized groups [41]