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In some embodiments, preparation of certain cations of Formulas I and IA may occur by alkylating the N-positions of the quinoline scaffold using, for example, iodomethane or methyl trifluoromethanesulfonate (see Scheme 1)

Abbreviations aRR: Adjusted RR BCAA: Branched-chain amino acid 1-C: Single carbon atoms FPG: Fasting plasma glucose GDM: Gestational diabetes mellitus 2 h-PG: 2 h post-load plasma glucose IADPSG: International Association of Diabetes and Pregnancy Study Groups IADPSG-GDM: GDM diagnosis based on IADPSG criteria LCMS: Liquid chromatography mass spectrometry miRNA: MicroRNA NICE: National Institute for Health and Care Excellence NICE-GDM: GDM diagnosis based on NICE criteria SES: Socioeconomic status tHcy: Total homocysteine References Saravanan P, Diabetes in Pregnancy Working Group, Maternal Medicine Clinical Study Group, Royal College of Obstetricians and Gynaecologists, UK (2020) Gestational diabetes: opportunities for improving maternal and child health

female, 4.0-5.4 x 10 6 /L), hemoglobin (Hb, normal range: male, 13-17 g/dL

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Recordkeeping: Record the preparation date, concentration, storage temperature, and applicable disposal date