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Research from the New England Journal of Medicine has concluded that substance use including nicotine causes the following changes in the brain: Desensitizes the brains reward circuit, dampening the brains ability to feel pleasure and motivation in everyday activities Increases the strength and intensity of conditioned responses, including reactivity to stress, which in turn produces stronger cravings for alcohol and other drugsas well as negative emotions when cravings go unsatisfied Weakens regions of the brain involved in executive functioning, like decision-making, impulse control and self-regulationall of which increase your relapse potential E-cigarettes are not safe for anyone, period

Retrieved 6 September 2023

In 1977, the American Cancer Society took its fight against cigarette smoking to the public when it sponsored the Great American Smokeout, issuing a challenge to smokers to stop smoking for a day

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Nicotine e-cigarettes also remain a risk for people whove never smoked, as the vapes might get someone hooked on nicotine, researchers said