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doi: 10.3390/ijms22073661 135 Osei-HyiamanDDePetrilloMPacherPLiuJRadaevaSBtkaiSet al

Rather than trying to dissolve a clot or mechanically open a blocked vessel, the body routes around the obstruction using upgraded alternative pathways

146,147,148,149 The CRISPR-mediated gene-editing system primarily involves Cas9 and single guide RNA (sgRNA) to introduce DNA double-strand breaks (DSBs) at specific positions in the genome