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260 Since the Notch signaling is a potentially attractive target candidate in atherosclerosis, further research is needed to elucidate the distinct biological roles of Notch receptors and ligands in the plaque progression and to validate the individual potentials as novel therapeutic strategies

ACS Biomaterials Science & Engineering

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In mouse experiments, Klevay and Viestenz (116) observed that copper-deficient rats exhibited a range of electrocardiographic abnormalities, including ST-segment depression spanning one-third to one-half of the RR interval, bundle-branch block with R-wave heights and widths three times the normal values, Q-waves, and second- and third-degree heart block

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