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Botond, et al

Nat Rev Immunol 11: 723737 Okabe Y, Medzhitov R (2014) Tissuespecific signals control reversible program of localization and functional polarization of macrophages

Alterations in glucose metabolism are early indicators of neurodegenerative disorders, with glucose hypometabolism being a hallmark of AD

106 Evidence for selective serotonin reuptake inhibitors (SSRIs) is mixed, and an RCT reported that sertraline significantly reduced tinnitus loudness and severity, 107 whereas paroxetine, with or without the neurokinin-1 antagonist vestipitant, showed no benefit

Table 1 summarizes the role of amino acid metabolism in DKD, covering microbial pathways, uremic toxins, and renal effects

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