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A 90-day nose-only inhalation exposure showed that IQOS had less impact than CS on body weight, hyperplasia and squamous metaplasia in the upper airway, lung inflammation, and overall biological impact (assessed by transcriptomic analysis)

These were age in years (for every year between 2013 and 2018), sex (male, female), and ethnicity (European and Other

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Amitriptyline shows particularly high rates, affecting 30-50% of patients with moderate to severe intensity [1]