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In another study, male mice were given CGA or a dietary supplement containing CGA and chromium (III)

This can lead to oxidative stress and tissue damage

To contextualize the need for this integrative approach, Table 1 provides a concise comparison including benefits and drawbacks between existing diagnostic and therapeutic frameworks, and the added mechanistic value offered by the proposed workflow (De Strooper and Karran, 2016

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AML cells are completely dependent on exogenous GLN, and knockdown of high-affinity ASCT2 leads to apoptosis in AML cell lines and inhibits tumor progression in AML xenografts and primary AML mouse models [47] Indeed, ASCT2 plays pleiotropic roles in cellular metabolism and serves as a promising molecular target for the treatment of leukemia [27]

(2008) How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis