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Be skeptical of high absorption hype: formulations like dihydroberberine and berberine phytosome have small human pharmacokinetic studies showing higher blood levels than standard berberine, but that does not automatically mean better real-world weight loss

The most clinically recommended options include hydroquinone (24%), which reduces melanin production, tretinoin, which speeds up cell turnover, and azelaic acid or kojic acid for sensitive skin

Douglas, J (2019)

The primary antibodies were visualized using goat anti-rabbit Alexa Fluor 555 conjugate and goat anti-mouse Alexa Fluor 488 conjugate antibodies (1:800) (Cell Signaling Technology)

Consequently, dogs and cats, as target species and animal models, may benefit from these findings

Jagdeo, J., Ho, D., Lo, A